Signaling is at the core of coordination between cells in multicellular organisms. Many experimental and computational studies are dedicated to deciphering the mechanisms underlying the specificity, efficiency and biological outputs of cell signaling networks. The primary role of the dynamical information conveyed by these networks is becoming increasingly evident, as revealed by the observation of delays, oscillations, or differential control of transient versus sustained responses.
In this one-day symposium, we aim at presenting a state-of-the-art view of how cells encode and decode spatio-temporal signals. The question is addressed through a combined experimental and modelling approach. Presentations will focus on interdisciplinary works at the interface between biology, physics and mathematics and investigating different signaling pathways (calcium, G-protein-coupled receptors and tyrosine-kinase receptors) involved in various biological contexts such as cellular adhesion, morphogenesis, endocrinology, neuroscience or cancer. The interdisciplinary approach is expected to lead to a unique cross-fertilization of ideas between scientists focusing on widely different time-regulated biological systems.
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